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SYNTHESIS, CHARACTERISATION AND DNA PHOTOCLEAVAGE ACTIVITY OF NEW 2-(THIOXO/OXO) QUINOLINE-4,6-DIMETHYL PYRIMIDINYL HYDRAZONES suggestion

Objective: The main objective of present work is to synthesize, characterize and evaluate DNA photocleavage activity of hydrazones containing
quinoline and pyrimidine rings.
Methods: The syntheses of new 2-(Thioxo/Oxo)quinoline-4,6-dimethyl pyrimidinyl hydrazones has been achieved by the reaction of 2-
(Thioxo/Oxo)quinoline-3-carbaldehydes and 2-hydrazino-4, 6-dimethylpyrimidine. The structure of synthesized compounds is established on basis
of data obtained from the spectroscopic techniques such as 1H NMR, 13
Results: The synthesized compounds 5e showed complete cleavage of DNA while 5a, 5b and 6e showed significant cleavage potential.
C NMR, FT-IR and mass. The synthesized compounds were evaluated for their
DNA photocleavage activity at 40 μg/μl concentration by agarose gel electrophoresis method.
Conclusion: A series of novel hydrazones bearing quinoline and pyrimidine moiety has been synthesized and well characterized on the basis of
spectroscopic data and further evaluated for their DNA photocleavage activity. It has been observed that compounds having bromo and thio group
displayed good activity.

ajay 2017-08-28 07:44
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